The World Cup 2010 Group A game between South Africa and Uruguay, the first of the tournament’s second round will be played at the Loftus Versfield Stadium on Wednesday June 16 2010, kick off set for 7:30 PM BST,2:30 PM EDT.This is a game that neither side can afford to lose. South Africa will evidently rely on an immense support from the fans at the old school Loftus Versfeld stadium and the side need a victory to keep the local party alive. After exchanging victory for a draw in the last 10 minutes of the match against Mexico in the tournament opener, South Africa will have to be going hard against Uruguay in Pretoria in a bid to avoid a first round exit.Indeed they do no want to become the first host nation to accomplish that negative feat. With the challenge of France coming up last, the Bafana Bafana have clearly squandered a golden opportunity against the Mexican squad after conceding a late equalizer and they will feel the intense pressure come Wednesday’s fixture.South Africa coach Carlos Parreira is likely to put experienced left back Tsepo Masilela on the starting line up. He replaced Lucas Thwala in the second half against Mexico.Uruguay’s Nicolas Lodeiro, who came on as a substitute against France only to be sent off for two yellow cards, is suspended for the match against Sough Africa.